@Article{096504018X15193506006164,
AUTHOR = {Shihui Liu, Xiuxiu Li, Sujing Zhuang},
TITLE = {miR-30c Impedes Glioblastoma Cell Proliferation and  Migration by Targeting SOX9},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {2},
PAGES = {165--171},
URL = {http://www.techscience.com/or/v27n2/48641},
ISSN = {1555-3906},
ABSTRACT = {miR-30c has been acknowledged as a tumor suppressor in various human cancers, such as ovarian cancer, gastric cancer, and prostate cancer. However, the role of miR-30c in glioblastoma (GBM) needs to be investigated. 
In our study, we found that the expression of miR-30c was significantly downregulated in GBM tissues and 
cell lines. We found that overexpression of miR-30c inhibited cellular proliferation of GBM cells in vitro and 
in vivo. More GBM cells were arrested in the G<sub>0</sub> phase after miR-30c overexpression. Moreover, we showed 
that miR-30c overexpression suppressed the migration and invasion of GBM cells. Mechanistically, we found 
that SOX9 was a direct target of miR-30c in GBM cells. Overexpression of miR-30c inhibited the mRNA 
and protein levels of SOX9 in GBM cells. Moreover, there was a negative correlation between the expression 
of miR-30c and SOX9 in GBM tissues. Finally, we showed that restoration of SOX9 in GBM cells reversed 
the proliferation, migration, and invasion of GBM cells transfected with miR-30c mimic. Collectively, our 
results demonstrated that miR-30c suppressed the proliferation, migration, and invasion of GBM cells via 
targeting SOX9.},
DOI = {10.3727/096504018X15193506006164}
}