@Article{096504018X15213089759999,
AUTHOR = {Dandan Wu,
 Jun Liu,
 Jianliang Chen, Haiyan He, Hang Ma, Xuedong Lv},
TITLE = {miR-449a Suppresses Tumor Growth, Migration, and Invasion in Non-Small  Cell Lung Cancer by Targeting a HMGB1-Mediated NF-kB Signaling Pathway},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {2},
PAGES = {227--235},
URL = {http://www.techscience.com/or/v27n2/48648},
ISSN = {1555-3906},
ABSTRACT = {MicroRNAs (miRNAs) have been reported to be involved in many human cancers and tumor progression. The 
dysregulation of miR-449a is found in many types of malignancies and is associated with tumor growth, migration, and invasion. However, its expression and function in non-small cell lung cancer (NSCLC) still remains 
unclear. In our study, miR-449a was found to be downregulated in both NSCLC tissues and cell lines, and 
low miR-449a expression was obviously associated with tumor differentiation, TMN stage, and poor overall 
survival (OS). Moreover, we demonstrated that miR-449a could inhibit tumor proliferation, migration, and 
invasion in NSCLC. We also confirmed that HMGB1 was a direct target gene of miR-449a in NSCLC with 
dual-luciferase reporter assay, and upregulation of HMGB1 could reverse the miR-449a-induced suppression 
of growth, migration, and invasion in NSCLC cells. Last, we found that miR-449a suppressed tumor initiation 
and development through the NF- B signaling pathway. These results indicate that miR-449a functions as a 
tumor suppressor in NSCLC by targeting the HMGB1-mediated NF- B signaling pathway in NSCLC.},
DOI = {10.3727/096504018X15213089759999}
}