TY  - EJOU
AU  - Wu, Dandan 
AU  - Liu, Jun 
AU  - Chen, Jianliang 
AU  - He, Haiyan 
AU  - Ma, Hang 
AU  - Lv, Xuedong 

TI  - miR-449a Suppresses Tumor Growth, Migration, and Invasion in Non-Small  Cell Lung Cancer by Targeting a HMGB1-Mediated NF-kB Signaling Pathway
T2  - Oncology Research

PY  - 2019
VL  - 27
IS  - 2
SN  - 1555-3906

AB  - MicroRNAs (miRNAs) have been reported to be involved in many human cancers and tumor progression. The 
dysregulation of miR-449a is found in many types of malignancies and is associated with tumor growth, migration, and invasion. However, its expression and function in non-small cell lung cancer (NSCLC) still remains 
unclear. In our study, miR-449a was found to be downregulated in both NSCLC tissues and cell lines, and 
low miR-449a expression was obviously associated with tumor differentiation, TMN stage, and poor overall 
survival (OS). Moreover, we demonstrated that miR-449a could inhibit tumor proliferation, migration, and 
invasion in NSCLC. We also confirmed that HMGB1 was a direct target gene of miR-449a in NSCLC with 
dual-luciferase reporter assay, and upregulation of HMGB1 could reverse the miR-449a-induced suppression 
of growth, migration, and invasion in NSCLC cells. Last, we found that miR-449a suppressed tumor initiation 
and development through the NF- B signaling pathway. These results indicate that miR-449a functions as a 
tumor suppressor in NSCLC by targeting the HMGB1-mediated NF- B signaling pathway in NSCLC.
KW  - miR-449a; Non-small cell lung cancer (NSCLC); High-mobility group box 1 (HMGB1);  NF- B

DO  - 10.3727/096504018X15213089759999