@Article{096504018X15219188894056,
AUTHOR = {Liyan Dou,
 Kaiyu Han,
 Mochao Xiao, Fuzhen Lv},
TITLE = {miR-223-5p Suppresses Tumor Growth and Metastasis in Non-Small  Cell Lung Cancer by Targeting E2F8},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {2},
PAGES = {261--268},
URL = {http://www.techscience.com/or/v27n2/48651},
ISSN = {1555-3906},
ABSTRACT = {miR-223-5p has been demonstrated to regulate the development and progression of various cancers, such 
as hepatocellular carcinoma, breast cancer, and gastric carcinoma. However, the role of miR-223-5p in nonsmall cell lung cancer (NSCLC) requires further investigation. In this study, we found that the expression 
of miR-223-5p was significantly downregulated in NSCLC tissues and cell lines. Moreover, the expression 
level of miR-223-5p is negatively correlated with the malignance of NSCLC. We found that overexpression 
of miR-223-5p remarkably suppressed the proliferation of NSCLC cells in vitro and in vivo. miR-223-5p 
overexpression also led to reduced migration and invasion in NSCLC cells. Mechanistically, we found that 
E2F8, a key transcription factor involved in many kinds of biological processes, was a direct target gene of 
miR-223-5p. Overexpression of miR-223-5p significantly decreased the mRNA and protein levels of E2F8 in 
NSCLC cells. We also showed that restoration of E2F8 rescued the proliferation, migration, and invasion of 
miR-223-5p-overexpressing NSCLC cells. Taken together, our findings demonstrated that miR-223-5p suppressed NSCLC progression through targeting E2F8.},
DOI = {10.3727/096504018X15219188894056}
}