@Article{096504018X15215019227688,
AUTHOR = {Jiangtao Liu, Yanli Jia, Lijuan Jia, Tingting Li, Lei Yang, Gongwen Zhang},
TITLE = {MicroRNA 615-3p Inhibits the Tumor Growth and Metastasis  of NSCLC via Inhibiting IGF2},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {2},
PAGES = {269--279},
URL = {http://www.techscience.com/or/v27n2/48652},
ISSN = {1555-3906},
ABSTRACT = {MicroRNAs are essential regulators of cancer-associated genes at the posttranscriptional level, and their 
expression is altered in cancer tissues. Herein we sought to identify the regulation of miR-615-3p in NSCLC 
progression and its mechanism. miR-615-3p expression was significantly downregulated in NSCLC tissue 
compared to control normal tissue. Exogenous overexpression of miR-615-3p inhibited the growth and metastasis of NSCLC cells. In addition, the in vivo mouse xenograft model showed that overexpression of miR-
615-3p inhibited NSCLC growth and lung metastasis, whereas decreased expression of miR-615-3p caused an 
opposite outcome. Furthermore, we revealed that insulin-like growth factor 2 (IGF2) expression was negatively 
correlated with the miR-615-3p level in NSCLC specimens, and IGF2 knockdown mimicked the effect of miR-
615-3p inhibition on NSCLC cell proliferation, migration, and invasion. In addition, overexpression of IGF2 
rescued the inhibition of miR-615-3p in NSCLC cells. Together, our results indicated that miR-615-3p played 
important roles in the regulation of NSCLC growth and metastasis by targeting IGF2.},
DOI = {10.3727/096504018X15215019227688}
}