@Article{096504019X15476499940873,
AUTHOR = {Jianlin Wang,
 Wenjie Song,
 Weiwei Shen,
 Xisheng Yang, Wei Sun, Sshibin Qu, Runze Shang, 
Ben Ma, Meng Pu, Kaishan Tao, Kefeng Dou, Haimin Li},
TITLE = {MicroRNA-200a Suppresses Cell Invasion and Migration by Directly Targeting  GAB1 in Hepatocellular Carcinoma},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {2},
PAGES = {281--282},
URL = {http://www.techscience.com/or/v27n2/48653},
ISSN = {1555-3906},
ABSTRACT = {MicroRNA-200a (miR-200a) is frequently downregulated in most cancer types and plays an important role 
in carcinogenesis and cancer progression. In this study, we determined that miR-200a was downregulated 
in hepatocellular carcinoma (HCC) tissues and cell lines, consistent with the results of our previous study. 
Because a previous study suggested that downregulation of miR-200a is correlated with HCC metastasis, we 
aimed to elucidate the mechanism underlying the role of miR-200a in metastasis in HCC. Here we observed 
that overexpression of miR-200a resulted in suppression of HCC metastatic ability, including HCC cell migration, invasion, and metastasis, in vitro and in vivo. Furthermore, bioinformatics and luciferase reporter assays 
indicated that GAB1 is a direct target of miR-200a. Inhibition of GAB1 resulted in substantially decreased cell 
invasion and migration similar to that observed with overexpression of miR-200a in HCC cell lines, whereas 
restoration of GAB1 partially rescued the inhibitory effects of miR-200a. Taken together, these data provide 
novel information for comprehending the tumor-suppressive role of miR-200a in HCC pathogenesis through 
inhibition of GAB1 translation.},
DOI = {10.3727/096504019X15476499940873}
}