@Article{096504018X15190399381143,
AUTHOR = {Fengyu Huang, Hongjun Zhao, Zhaojin Du, Hong Jiang},
TITLE = {miR-615 Inhibits Prostate Cancer Cell Proliferation and Invasion  by Directly Targeting Cyclin D2},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {3},
PAGES = {293--299},
URL = {http://www.techscience.com/or/v27n3/48591},
ISSN = {1555-3906},
ABSTRACT = {Previous studies have reported that miR-615 exerts a tumor suppressor role in some tumors, such as esophageal 
squamous cell carcinoma and non-small cell lung cancer. However, the role of miR-615 in prostate cancer has 
not been defined. Here we found that miR-615 was downregulated in prostate cancer tissues and cell lines. 
Overexpression of miR-615 in PC-3 cells significantly inhibited cellular proliferation, migration, and invasion. 
Moreover, overexpression of miR-615 delayed tumor growth in vivo. In terms of mechanism, we found that 
cyclin D2 (CCND2) is a target gene of miR-615 in prostate cancer. We showed that miR-615 could bind to 
the 3 -UTR region of CCND2 mRNA and inhibit its expression. There was a negative correlation between the 
expression of miR-615 and CCND2 in prostate cancer tissues. Moreover, restoration of cyclin D2 abolished 
the inhibitory effects of miR-615 on the proliferation, migration, and invasion of prostate cancer cells. Taken 
together, our study identified miR-615 as a tumor suppressor by targeting cyclin D2 in prostate cancer.},
DOI = {10.3727/096504018X15190399381143}
}