@Article{096504018X15228863026239,
AUTHOR = {Xiyan Sun,
 Chao Zhang,
 Yang Cao, Erbiao Liu},
TITLE = {miR-150 Suppresses Tumor Growth in Melanoma  Through Downregulation of MYB},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {3},
PAGES = {317--323},
URL = {http://www.techscience.com/or/v27n3/48594},
ISSN = {1555-3906},
ABSTRACT = {miR-150 has been demonstrated to inhibit tumor progression in various human cancers, including colorectal 
cancer, ovarian cancer, and thyroid cancer. However, the role of miR-150 in melanoma remains to be determined. In this study, we found that miR-150 was underexpressed in melanoma tissues and cell lines. Through 
transfection of miR-150 mimics, we found that miR-150 significantly inhibited the proliferation, migration, 
and invasion of melanoma cells. In mechanism, we found that MYB was a target of miR-150 in melanoma 
cells. Overexpression of miR-150 significantly inhibited mRNA and protein levels of MYB in melanoma cells. 
Moreover, there was an inverse correlation between the expression of miR-150 and MYB in melanoma tissues. 
We also showed that MYB was upregulated in melanoma tissues and cell lines. Through functional experiments, we found that restoration of MYB in miR-150-overexpressed melanoma cells rescued the proliferation, migration, and invasion. Therefore, our findings demonstrated that miR-150 suppressed the proliferation, 
migration, and invasion of melanoma cell by downregulating MYB.},
DOI = {10.3727/096504018X15228863026239}
}