@Article{096504018X15251282086836,
AUTHOR = {Hao Chen, Yi Zhang, Hai Su, Hui Shi, Qijiang Xiong, Zulu Su},
TITLE = {Overexpression of miR-1283 Inhibits Cell Proliferation and Invasion  of Glioma Cells by Targeting ATF4},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {3},
PAGES = {325--334},
URL = {http://www.techscience.com/or/v27n3/48595},
ISSN = {1555-3906},
ABSTRACT = {It is well known that activating transcription factor 4 (ATF4) expression is closely associated with progression 
of many cancers. We found that miR-1283 could directly target ATF4. However, the precise mechanisms of 
miR-1283 in glioma have not been well clarified. Our study aimed to explore the interaction between ATF4 and 
miR-1283 in glioma. In this study, we found that the level of miR-1283 was dramatically decreased in glioma 
tissues and cell lines, the expression of ATF4 was significantly increased, and the low level of miR-1283 was 
closely associated with high expression of ATF4 in glioma tissues. Moreover, introduction of miR-1283 significantly inhibited proliferation and invasion of glioma cells. However, knockdown of miR-1283 promoted 
the proliferation and invasion in glioma cells. Bioinformatics analysis predicted that the ATF4 was a potential 
target gene of miR-1283. Luciferase reporter assay demonstrated that miR-1283 could directly target ATF4. In 
addition, knockdown of ATF4 had similar effects with miR-1283 overexpression on glioma cells. Upregulation 
of ATF4 in glioma cells partially reversed the inhibitory effects of miR-1283 mimic. Overexpression of miR-
1283 inhibited cell proliferation and invasion of glioma cells by directly downregulating ATF4 expression.},
DOI = {10.3727/096504018X15251282086836}
}