@Article{096504018X15252202178408,
AUTHOR = {Haiyan Zhang, Yanxia Lu, Surong Wang, Xiugui Sheng, Shiqian Zhang},
TITLE = {MicroRNA-152 Acts as a Tumor Suppressor MicroRNA  by Inhibiting Krüppel-Like Factor 5 in Human Cervical Cancer},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {3},
PAGES = {335--340},
URL = {http://www.techscience.com/or/v27n3/48596},
ISSN = {1555-3906},
ABSTRACT = {Aberrant expression of microRNA-152 (miR-152) is frequently observed in human cancers including ovarian cancer, breast cancer, prostate cancer, and gastric cancer. However, its expression and functional role in 
cervical cancer (CC) are poorly understood. Also, the association between miR-152 and Krüppel-like factor 5 
(KLF5) expression in CC remains unclear. In this study, analyzing the expression of miR-152 by quantitative 
real-time PCR (qRT-PCR) revealed it was sharply reduced in CC tissues and cell lines. In addition, the negative correlation of miR-152 expression and KLF5 expression was observed. The dual-luciferase reporter assay 
validated that KLF5 was a target of miR-152. In vitro functional assays revealed that miR-152 could inhibit cell 
proliferation and cell cycle progression through regulating the expression of KLF5. Taken together, our study 
suggested that miR-152 functions as a tumor suppressor in CC, and the miR-152/KLF5 axis may provide novel 
therapeutic targets for CC treatment.},
DOI = {10.3727/096504018X15252202178408}
}