@Article{096504018X15228909735079,
AUTHOR = {Yan Gao, Yongchuan Xu, Jue Wang, Xue Yang, Lulu Wen, Juan Feng},
TITLE = {lncRNA MNX1-AS1 Promotes Glioblastoma Progression  Through Inhibition of miR-4443},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {3},
PAGES = {341--347},
URL = {http://www.techscience.com/or/v27n3/48597},
ISSN = {1555-3906},
ABSTRACT = {Long noncoding RNAs (lncRNAs) have been acknowledged as important regulators in various human cancers. 
lncRNA MNX1-AS1 has been shown to be an oncogene in epithelial ovarian cancer. However, the function of MNX1-AS1 in glioblastoma (GBM) remains largely unknown. Here we found that the expression of 
MNX1-AS1 was significantly upregulated in GBM tissues and cell lines. Knockdown of MNX1-AS1 significantly inhibited the proliferation, migration, and invasion of GBM cells. In terms of mechanism, we found that 
MNX1-AS1 could bind to miR-4443 in GBM cells. Overexpression of miR-4443 significantly inhibited the 
expression of MNX1-AS1 and vice versa. Moreover, there was an inverse correlation between the expression 
levels of MNX1-AS1 and miR-4443 in GBM tissues. We found that overexpression of miR-4443 inhibited 
the proliferation, migration, and invasion of GBM cells. We also showed that inhibition of miR-4443 reversed 
the effects of MNX1-AS1 knockdown on GBM cell proliferation, migration, and invasion. Taken together, we 
found that MNX1-AS1 promoted the proliferation, migration, and invasion of GBM cells through inhibiting 
miR-4443.},
DOI = {10.3727/096504018X15228909735079}
}