@Article{096504018X15199531937158,
AUTHOR = {Yang Zhang, Min Zhu, Yuanbo Sun, Wenyuan Li, Ying Wang, Weiguang Yu},
TITLE = {Upregulation of lncRNA CASC2 Suppresses Cell Proliferation and Metastasis  of Breast Cancer via Inactivation of the TGF-β Signaling Pathway},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {3},
PAGES = {379--387},
URL = {http://www.techscience.com/or/v27n3/48601},
ISSN = {1555-3906},
ABSTRACT = {Breast cancer is one of the major malignancies with a mounting mortality rate in the world. Long noncoding 
RNA (lncRNA) cancer susceptibility candidate 2 (CASC2) has been identified to regulate the initiation 
and progression of multiple tumorous diseases according to previous studies. However, its biological role 
has been rarely reported in breast cancer. In the present study, lncRNA CASC2 was found to be significantly 
downregulated in breast cancer tissues and cell lines using real-time quantitative PCR. Furthermore, gain-offunction assays demonstrated that overexpression of lncRNA CASC2 significantly repressed breast cancer cell 
proliferation and metastasis. Moreover, CASC2 induced cell cycle arrest and much more early apoptosis of 
breast cancer. Additionally, based on the above research, we illustrated that inactivation of the TGF- signaling 
pathway was involved in the function of lncRNA CASC2. Collectively, lncRNA CASC2 was a key factor in 
the tumorigenesis and malignancy of breast cancer, suggesting it may possibly be a potential therapy target for 
the treatment of breast cancer.},
DOI = {10.3727/096504018X15199531937158}
}