@Article{096504017X15030178624579,
AUTHOR = {Hai-Tao Li, Dao-Yong Dong, Qiang Liu, Yi-Qin Xu, Langbo Chen},
TITLE = {Overexpression of LACTB, a Mitochondrial Protein That Inhibits  Proliferation and Invasion in Glioma Cells},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {4},
PAGES = {423--429},
URL = {http://www.techscience.com/or/v27n4/48555},
ISSN = {1555-3906},
ABSTRACT = {LACTB, a mitochondrial protein, was ubiquitously expressed in different mammalian tissues, such as liver, 
heart, and skeletal muscle. It has been shown that LACTB is downexpressed in breast cancers, and it suppresses the proliferation and promotes the apoptosis of breast cancers. However, its role in the progression 
and prognosis of glioma remains unknown. In this study, we analyzed the clinicopathological features and 
outcomes of LACTB expression in 98 glioma patients and investigated the effects of LACTB overexpression 
on the proliferation, invasion, and angiogenesis of glioma cells in vitro. We observed a significant decrease in 
LACTB expression in glioma, and downexpression of LACTB is correlated with a poor prognosis of glioma 
patients. Moreover, Cox regression analysis reveals that the LACTB is an independent prognostic indicator 
for glioma patients. Overexpression of LACTB could suppress the proliferation, invasion, and angiogenesis of 
glioma cells. In addition, overexpression of LACTB could inhibit the expression of PCNA, MMP2, MMP9, 
and VEGF. Taken together, these data indicate that LACTB may serve as a promising therapeutic target for 
gliomas.},
DOI = {10.3727/096504017X15030178624579}
}