@Article{096504018X15201058168730,
AUTHOR = {Xin Chen, Mingzhe Li, Hongwei Zhou, Li Zhang},
TITLE = {miR-132 Targets FOXA1 and Exerts Tumor-Suppressing  Functions in Thyroid Cancer},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {4},
PAGES = {431--437},
URL = {http://www.techscience.com/or/v27n4/48556},
ISSN = {1555-3906},
ABSTRACT = {MicroRNA-132 (miR-132) has been demonstrated to be a tumor suppressor in several types of tumors. However, 
the expression and the role of miR-132 in human thyroid cancer are still poorly understood. The aim of the 
present study was to examine the potential roles and molecular mechanism of miR-132 in thyroid cancer. We 
found that miR-132 expression levels were significantly downregulated in thyroid cancer tissues and cell lines. 
Function assays showed that overexpression of miR-132 in TPC1 cells inhibited cell proliferation, migration, 
and invasion. Forkhead box protein A1 (FOXA1) was identified as a direct target of miR-132 in thyroid cancer 
cells. Knockdown of FOXA1 in TPC1 cells significantly inhibited cell proliferation, migration, and invasion, 
which mimicked the suppressive effect induced by miR-132 overexpression. Restoration of FOXA1 expression 
partially reversed the suppressive effect induced by miR-132 overexpression. Taken together, these results suggested that miR-132 acts as a tumor suppressor in thyroid cancer through targeting FOXA1.},
DOI = {10.3727/096504018X15201058168730}
}