@Article{096504017X15016337254623,
AUTHOR = {Guoyun Li, Wei Zhang, Li Gong, Xiaoping Huang},
TITLE = {MicroRNA 125a-5p Inhibits Cell Proliferation and Induces Apoptosis  in Hepatitis B Virus-Related Hepatocellular Carcinoma  by Downregulation of ErbB3},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {4},
PAGES = {449--458},
URL = {http://www.techscience.com/or/v27n4/48558},
ISSN = {1555-3906},
ABSTRACT = {MicroRNAs, a class of endogenous noncoding RNAs, regulate gene expression at the posttranscriptional level 
and thus take part in multiple biological processes. An increasing number of miRNAs have been found to be 
dysregulated in hepatocellular carcinoma (HCC) and are involved in liver tumorigenesis. In this study, miR-
125a-5p was found to be obviously downregulated much more in hepatitis B virus (HBV)-related HCC. To 
investigate the effects of miR-125a-5p, miR-125a-5p was overexpressed in HepG2.2.15 and HepG3X cells. 
The findings have indicated that overexpression of miR-125a-5p dramatically inhibited cell proliferation and 
induced cell apoptosis. Furthermore, overexpression of miR-125a-5p could significantly decrease the secretion 
of HBsAg and HBeAg. In concordance to this, the expression of ErbB3 was upregulated in human HBV-related 
HCC tissue, HepG2.2.15 cells, and HepG3X cells. miR-125a-5p directly targeted ErbB3 and reduced both 
mRNA and protein levels of ErbB3, which promoted cell proliferation and suppressed cell apoptosis in HCC 
cells. Our results provide new insights into the function of miR-125a-5p in HBV-related HCC. It is beneficial 
to gain insight into the mechanism of HBV infection and pathophysiology of HBV-related HCC.},
DOI = {10.3727/096504017X15016337254623}
}