@Article{096504018X15278771272963,
AUTHOR = {Qiaodong Xu, Songgang Gu, Jiahong Liang, Zhihua Lin, Shaodong Zheng, Jiang Yan},
TITLE = {The Biological Function of Hepatitis B Virus X  Protein in Hepatocellular Carcinoma},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {4},
PAGES = {509--514},
URL = {http://www.techscience.com/or/v27n4/48565},
ISSN = {1555-3906},
ABSTRACT = {Hepatocellular carcinoma (HCC) is one of the major malignant tumors that lead to death. Chronic hepatitis B 
virus infection is an important risk factor for HCC initiation. HBx protein, encoded by the HBV X gene, is a 
significant factor that promotes HBV-related HCC, although the exact molecular mechanism remains unclear. 
This article summarizes the pathological roles and related mechanisms of HBx in HCC. HBx plays a carcinogenic role by promoting cell proliferation, metastasis, and angiogenesis and inhibiting apoptosis in HCC. A 
detailed study of the biological functions of HBx will help to elucidate the mechanism of hepatocarcinogenesis 
and lead to the development of novel therapeutic targets for the treatment of HBV-related HCC.},
DOI = {10.3727/096504018X15278771272963}
}