@Article{096504018X15199489058224,
AUTHOR = {Xiaoying Han, Jing Yang, Dong Li, Zewei Guo},
TITLE = {Overexpression of Uric Acid Transporter SLC2A9 Inhibits Proliferation  of Hepatocellular Carcinoma Cells},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {5},
PAGES = {533--540},
URL = {http://www.techscience.com/or/v27n5/48568},
ISSN = {1555-3906},
ABSTRACT = {Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated mortality worldwide. Although 
the mechanisms of HCC progression are not well understood, recent studies demonstrated the potential contribution of uric acid transporter SLC2A9 to tumor suppression. However, the roles and underlying mechanisms are still unknown. We aimed to study the roles and mechanisms of SLC2A9 in HCC. The present study 
showed that SLC2A9 expression was decreased in human HCC tissues and cell lines. In addition, overexpression of SLC2A9 inhibited HCC cell proliferation. SCL2A9 induced HCC cell apoptosis by inhibiting the 
expression of caspase 3. Our study also revealed that upregulation of SLC2A9 reduced intracellular reactive 
oxygen species (ROS) accumulation. Furthermore, SLC2A9 increased the mRNA and protein expression of 
tumor suppressor p53 in HCC cells. Probenecid inhibits SLC2A9-mediated uric acid transport, which promotes cell proliferation, inhibits cell apoptosis, induces intracellular ROS, and decreases the expression of 
p53 in HCC cells. Therefore, the present study demonstrated that SLC2A9 may be a novel tumor suppressor 
gene and a potential therapeutic target in HCC.},
DOI = {10.3727/096504018X15199489058224}
}