@Article{096504017X15051723858706,
AUTHOR = {Jun Shan Ruan, Huan Zhou, Lin Yang, Ling Wang, Zong Sheng Jiang, Hong Sun, Shao Ming Wang},
TITLE = {Ursolic Acid Attenuates TGF-b1-Induced Epithelial–Mesenchymal Transition in  NSCLC by Targeting Integrin aVb5/MMPs Signaling},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {5},
PAGES = {593--600},
URL = {http://www.techscience.com/or/v27n5/48575},
ISSN = {1555-3906},
ABSTRACT = {Transforming growth factor- 1 (TGF- 1)-induced epithelial–mesenchymal transition (EMT) of non-small cell 
lung cancer (NSCLC) may contribute to tumor metastasis. TGF- 1-induced EMT in H1975 cells (a human 
NSCLC cell line) resulted in the adoption of mesenchymal responses that were predominantly mediated via 
the TGF- 1–integrin signaling pathway. Ursolic acid has been previously reported to inhibit tumor growth and 
metastasis in several cancers. However, whether ursolic acid can attenuate TGF- 1-induced EMT in H1975 
cells and its underlying mechanisms remain unknown. In this study, ursolic acid significantly attenuated the 
TGF- 1-induced decrease in E-cadherin level and elevated the level of N-cadherin. Furthermore, ursolic acid 
inhibited the mesenchymal-like responses in H1975 cells, including cell migration, invasion, and activity of 
matrix metallopeptidase (MMP)-2 and -9. Finally, our new findings provided evidence that ursolic acid could 
inhibit EMT in NSCLC through TGF- 1 signaling pathway-mediated integrin V 5 expression, and this might 
be the potential mechanism of resveratrol on the inhibition of invasion and metastases in NSCLC. We conclude 
that ursolic acid attenuated TGF- 1-induced EMT in H1975 cells and thus might be a promising therapeutic 
agent for treating NSCLC.},
DOI = {10.3727/096504017X15051723858706}
}