TY  - EJOU
AU  - Ruan, Jun Shan 
AU  - Zhou, Huan 
AU  - Yang, Lin 
AU  - Wang, Ling 
AU  - Jiang, Zong Sheng 
AU  - Sun, Hong 
AU  - Wang, Shao Ming 

TI  - Ursolic Acid Attenuates TGF-b1-Induced Epithelial–Mesenchymal Transition in  NSCLC by Targeting Integrin aVb5/MMPs Signaling
T2  - Oncology Research

PY  - 2019
VL  - 27
IS  - 5
SN  - 1555-3906

AB  - Transforming growth factor- 1 (TGF- 1)-induced epithelial–mesenchymal transition (EMT) of non-small cell 
lung cancer (NSCLC) may contribute to tumor metastasis. TGF- 1-induced EMT in H1975 cells (a human 
NSCLC cell line) resulted in the adoption of mesenchymal responses that were predominantly mediated via 
the TGF- 1–integrin signaling pathway. Ursolic acid has been previously reported to inhibit tumor growth and 
metastasis in several cancers. However, whether ursolic acid can attenuate TGF- 1-induced EMT in H1975 
cells and its underlying mechanisms remain unknown. In this study, ursolic acid significantly attenuated the 
TGF- 1-induced decrease in E-cadherin level and elevated the level of N-cadherin. Furthermore, ursolic acid 
inhibited the mesenchymal-like responses in H1975 cells, including cell migration, invasion, and activity of 
matrix metallopeptidase (MMP)-2 and -9. Finally, our new findings provided evidence that ursolic acid could 
inhibit EMT in NSCLC through TGF- 1 signaling pathway-mediated integrin V 5 expression, and this might 
be the potential mechanism of resveratrol on the inhibition of invasion and metastases in NSCLC. We conclude 
that ursolic acid attenuated TGF- 1-induced EMT in H1975 cells and thus might be a promising therapeutic 
agent for treating NSCLC.
KW  - Non-small cell lung cancer (NSCLC); Epithelial–mesenchymal transition (EMT);  Ursolic acid; Metastasis

DO  - 10.3727/096504017X15051723858706