@Article{096504018X15420734828058,
AUTHOR = {Wanjun Yu, Weidong Peng, Hanyun Sha, Jipeng Li},
TITLE = {Hsa_circ_0003998 Promotes Chemoresistance via Modulation of miR-326  in Lung Adenocarcinoma Cells},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {5},
PAGES = {623--628},
URL = {http://www.techscience.com/or/v27n5/48578},
ISSN = {1555-3906},
ABSTRACT = {Circular RNAs (circRNAs) represent a new class of noncoding RNAs that is involved in the development 
of cancer. However, little is known about their role in chemoresistance. In the present study, we found that 
hsa_circ_0003998 expression levels in lung adenocarcinoma (LAD) tissues and docetaxel-resistant cell lines 
(A549/DTX and H1299/DTX) were upregulated. Knockdown of hsa_circ_0003998 decreased chemoresistance, inhibited proliferation, and enhanced apoptosis in docetaxel-resistant LAD cells. Moreover, by using 
bioinformatics and luciferase reporter assays, we found that miR-326 was a direct target of hsa_circ_0003998. 
Functional analysis revealed that miR-326 mediated the effect of hsa_circ_0003998 on chemosensitivity. Our 
findings provide a molecular insight on understanding drug resistance in LAD cells. Therefore, inactivation of 
hsa_circ_0003998 or activation of miR-326 could be a novel approach for the treatment of LAD.},
DOI = {10.3727/096504018X15420734828058}
}