TY  - EJOU
AU  - Yu, Wanjun 
AU  - Peng, Weidong 
AU  - Sha, Hanyun 
AU  - Li, Jipeng 

TI  - Hsa_circ_0003998 Promotes Chemoresistance via Modulation of miR-326  in Lung Adenocarcinoma Cells
T2  - Oncology Research

PY  - 2019
VL  - 27
IS  - 5
SN  - 1555-3906

AB  - Circular RNAs (circRNAs) represent a new class of noncoding RNAs that is involved in the development 
of cancer. However, little is known about their role in chemoresistance. In the present study, we found that 
hsa_circ_0003998 expression levels in lung adenocarcinoma (LAD) tissues and docetaxel-resistant cell lines 
(A549/DTX and H1299/DTX) were upregulated. Knockdown of hsa_circ_0003998 decreased chemoresistance, inhibited proliferation, and enhanced apoptosis in docetaxel-resistant LAD cells. Moreover, by using 
bioinformatics and luciferase reporter assays, we found that miR-326 was a direct target of hsa_circ_0003998. 
Functional analysis revealed that miR-326 mediated the effect of hsa_circ_0003998 on chemosensitivity. Our 
findings provide a molecular insight on understanding drug resistance in LAD cells. Therefore, inactivation of 
hsa_circ_0003998 or activation of miR-326 could be a novel approach for the treatment of LAD.
KW  - Circular RNA (circRNA); hsa_circ_0003998; Chemoresistance; miR-326;  Lung adenocarcinoma (LAD)

DO  - 10.3727/096504018X15420734828058