TY  - EJOU
AU  - Li, Qiang 
AU  - Liu, Qi 
AU  - Cheng, Wanpeng 
AU  - Wei, Huiyan 
AU  - Jiang, Wenqian 
AU  - E, Fang 
AU  - Yu, an 
AU  - Jin, Jianfeng 
AU  - Zou, Chaoxia 

TI  - Heme Oxygenase-1 Inhibits Tumor Metastasis Mediated by Notch1 Pathway  in Murine Mammary Carcinoma
T2  - Oncology Research

PY  - 2019
VL  - 27
IS  - 6
SN  - 1555-3906

AB  - Heme oxygenase-1 (HO-1) plays an important role in the progression of several malignancies including breast 
cancer. However, its role in breast cancer metastasis is still ambiguous. In this study, we observed the effect of 
HO-1 on mouse mammary carcinoma metastasis using the in vivo tumor metastasis model. Our results revealed 
that overexpression of HO-1 strongly inhibits the lung metastasis of 4T1 cells. In in vitro analysis, associated 
indices for epithelial–mesenchymal transition (EMT), migration, and proliferation of 4T1 cells were evaluated. 
The results show that HO-1 inhibits EMT, migration, and proliferation of 4T1 cells. In addition, the Notch1/
Slug pathway is found to mediate an antimetastasis role of HO-1 in mouse mammary carcinoma. In conclusion, 
since HO-1/Notch1/Slug axis plays an important role in breast cancer metastasis, induction of HO-1 could be 
used as a potential therapeutic strategy for breast cancer treatment.
KW  - Murine mammary carcinoma; Heme oxygenase-1 (HO-1); Tumor metastasis;  Epithelial–mesenchymal transition (EMT); Notch1 signaling

DO  - 10.3727/096504018X15415906335771