@Article{096504018X15399955297355,
AUTHOR = {Juan Li,
 Chunyan Liu,
 Dawei Li, Meng Wan, Hong Zhang, Xiaoxia Zheng, Xuemei Jie, 
Pengju Zhang, Jingjing Li, Hongchun Hou, Qing Sun},
TITLE = {OLFM4 Inhibits Epithelial–Mesenchymal Transition  and Metastatic Potential of Cervical Cancer Cells},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {7},
PAGES = {763--771},
URL = {http://www.techscience.com/or/v27n7/48605},
ISSN = {1555-3906},
ABSTRACT = {OLFM4 has been shown to play an important role in tumor initiation and progression. This study aims to 
investigate the role of OLFM4 in metastatic cervical cancer and its underlying mechanism. Here we discover 
that OLFM4 expression is significantly reduced in metastatic cervical cancer. Accordingly, overexpression of 
OLFM4 inhibits epithelial–mesenchymal transition (EMT), migration, and invasion in human cervical cancer 
cells. To further explore its molecular mechanisms, we reveal that OLFM4 augmentation interferes with mTOR 
signaling pathway, and the suppressive effects of OLFM4 on cell migration and invasion are largely weakened 
by phosphatidic acid (PA)-induced mTOR signal activation, which implicates the potential role of the mTOR 
pathway in OLFM4-related cervical metastasis. In conclusion, our results confirm OLFM4 as a tumor suppressor that inhibits cervical cancer metastasis by regulating mTOR signal pathway.},
DOI = {10.3727/096504018X15399955297355}
}