@Article{096504018X15208986577685,
AUTHOR = {Teng Liu, Juan Xu, Hong Li Yan, Feng Chun Cheng, Xi Jie Liu},
TITLE = {Luteolin Suppresses Teratoma Cell Growth and Induces  Cell Apoptosis via Inhibiting Bcl-2},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {7},
PAGES = {773--778},
URL = {http://www.techscience.com/or/v27n7/48606},
ISSN = {1555-3906},
ABSTRACT = {Luteolin, which is found in plant foods, has a range of therapeutic applications. In order to examine the potential roles of luteolin in ovarian teratocarcinoma, the human ovarian teratocarcinoma cell line PA-1 was selected 
for functional experiments in vitro and in vivo. We demonstrated that luteolin inhibited the proliferation and 
colony formation of PA-1 cells in vitro. The flow cytometry results suggested that luteolin induced apoptosis 
of PA-1 cells in a dose-dependent manner. Immunofluorescence and qRT-PCR results showed that the expression of B-cell lymphoma-2 (Bcl-2) was decreased in luteolin-treated cells, whereas the expression of Bcl-2-
associated X (Bax) was increased compared with that in the control group. In addition, luteolin inhibited the 
tumor growth of ovarian teratocarcinoma cells in a xenograft model. All the results suggested that luteolin 
induced cell apoptosis and inhibited tumor growth of PA-1 cells.},
DOI = {10.3727/096504018X15208986577685}
}