@Article{096504018X15444387696532,
AUTHOR = {Jianye Li, Bin Zhang, Jizhao Cui, Zhen Liang, Kexia Liu},
TITLE = {miR-203 Inhibits the Invasion and EMT of Gastric Cancer Cells by Directly  Targeting Annexin A4},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {7},
PAGES = {789--799},
URL = {http://www.techscience.com/or/v27n7/48608},
ISSN = {1555-3906},
ABSTRACT = {Many studies have shown that downregulated miR-203 level is in a variety of cancers including gastric cancer 
(GC). However, the precise molecule mechanisms of miR-203 in GC have not been well clarified. In the current study, we investigated the biological functions and molecular mechanisms of miR-203 in GC cell lines. 
We found that miR-203 is downregulated in GC tissues and cell lines. Moreover, the low level of miR-203 
was associated with increased expression of annexin A4 in GC tissues and cell lines. The invasion and EMT 
of GC cells were suppressed by overexpression of miR-203. However, downregulation of miR-203 promoted 
invasion and EMT of GC cells. Bioinformatics analysis predicted that annexin A4 was a potential target gene of 
miR-203. Next, luciferase reporter assay confirmed that miR-203 could directly target annexin A4. Consistent 
with the effect of miR-203, downregulation of annexin A4 by siRNA inhibited the invasion and EMT of GC 
cells. Introduction of annexin A4 in GC cells partially blocked the effects of miR-203 mimic. Introduction of 
miR-203 directly targeted annexin A4 to inhibit the invasion and EMT of GC cells. Overall, reactivation of the 
miR-203/annexin A4 axis may represent a new strategy for overcoming metastasis of GC.},
DOI = {10.3727/096504018X15444387696532}
}