@Article{096504018X15451308507747,
AUTHOR = {Wei Wu, Linyan He, Yan Huang, Likun Hou, Wei Zhang, Liping Zhang, Chunyan Wu},
TITLE = {MicroRNA-510 Plays Oncogenic Roles in Non-Small Cell Lung Cancer  by Directly Targeting SRC Kinase Signaling Inhibitor 1},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {8},
PAGES = {879--887},
URL = {http://www.techscience.com/or/v27n8/48617},
ISSN = {1555-3906},
ABSTRACT = {An increasing number of studies have demonstrated that microRNAs (miRNAs) may play key roles in various 
cancer carcinogenesis and progression, including non-small cell lung cancer (NSCLC). However, the expressions, roles, and mechanisms of miR-510 in NSCLC have, up to now, been largely undefined. In vivo assay 
showed that miR-510 was upregulated in NSCLC tissues compared with that in adjacent nontumor lung tissues. 
miR-510 expression was significantly correlated with TNM stage and lymph node metastasis. In vitro assay 
indicated that expressions of miR-510 were also increased in NSCLC cell lines. Downregulation of miR-510 
suppressed NSCLC cell proliferation and invasion in vitro. We identified SRC kinase signaling inhibitor 1 
(SRCIN1) as a direct target gene of miR-510 in NSCLC. Expression of SRCIN1 was downregulated in lung 
cancer cells and negatively correlated with miR-510 expression in tumor tissues. Downregulation of SRCIN1, 
leading to inhibition of miR-510 expression, reversed cell proliferation and invasion in NSCLC cells. These 
results showed that miR-510 acted as an oncogenic miRNA in NSCLC, partly by targeting SRCIN1, suggesting 
that miR-510 can be a potential approach for the treatment of patients with malignant lung cancer.},
DOI = {10.3727/096504018X15451308507747}
}