@Article{096504018X15482423944678,
AUTHOR = {Yue Cai, Chizhi Zhang, Lei Zhan, Liangbin Cheng, Dingbo Lu, Xiaodong Wang, 
Hanlin Xu, Shuxue Wang, Deng Wu, Lianguo Ruan},
TITLE = {Anticancer Effects of <i>Gleditsia sinensis</i> Extract in Rats Transplanted  With Hepatocellular Carcinoma Cells},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {8},
PAGES = {889--899},
URL = {http://www.techscience.com/or/v27n8/48618},
ISSN = {1555-3906},
ABSTRACT = {The thorns of <i>Gleditsia sinensis</i> have been historically used in Chinese medicine and are considered one of the 
fundamental therapeutic herbs. Its anticancer effects are currently being explored. Hepatocellular carcinoma 
(HCC) is the most common type of primary liver cancer and still requires the development of new drugs with 
higher efficiency. By using a rat HCC model implanted with cancerous Walker-256 cells, the therapeutic effects 
of <i>G. sinensis</i> extract (GSE) were assessed, as well as its regulatory effects on miRNAs. GSE significantly 
restored liver morphology and dramatically induced cell apoptosis in HCC rats. In addition, miR-21/181b/183 
was upregulated in the HCC liver, and the elevation of these miRNAs could be alleviated by both GSE and 
sorafenib. PTEN/TIMP3/PDCD4 downregulation was consistent with the targets of miR-21/181b/183 in the 
HCC liver, and the alteration of these target genes was restored by both GSE and sorafenib. TIMP3 effects on 
MMP-2/9 expression were also determined. Our present findings indicate the potential of GSE in HCC treatment, and expand the understanding of miRNA-related mechanisms in the anticancer effects of GSE.},
DOI = {10.3727/096504018X15482423944678}
}