@Article{096504018X15336368805108,
AUTHOR = {Jian-Wei Wang, Xiao-Feng Wu, Xiao-Juan Gu, Xing-Hua Jiang},
TITLE = {Exosomal miR-1228 From Cancer-Associated Fibroblasts Promotes Cell  Migration and Invasion of Osteosarcoma by Directly Targeting SCAI},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {9},
PAGES = {979--986},
URL = {http://www.techscience.com/or/v27n9/48626},
ISSN = {1555-3906},
ABSTRACT = {Cancer-associated fibroblasts (CAFs) play a predominant role in regulating tumor progression. Understanding 
how CAFs communicate with osteosarcoma is crucial for developing novel approaches for osteosarcoma therapy. Exosomes are able to transmit messages between cells. In this study, we demonstrated that CAFs transfer 
exosomes to osteosarcoma cells, which promotes osteosarcoma cell migration and invasion. Using a miRNA 
microarray analysis, we identified 13 miRNAs that are significantly increased in exosomes derived from 
cancer-associated fibroblasts (CAFs) and corresponding paracancer fibroblasts (PAFs). In vitro studies further validated that the levels of microRNA-1228 (miR-1228) were increased in CAFs, its secreted exosomes, 
and in recipient osteosarcoma cells, which can downregulate endogenous SCAI mRNA and protein level in 
osteosarcoma. Furthermore, our findings demonstrate that SCAI was downregulated in osteosarcoma tissues. 
Taken together, this study provides evidence that CAF exosomal miR-1228 is able to promote osteosarcoma 
invasion and migration by targeting SCAI, which may represent a critical therapeutic target for osteosarcoma 
treatment.},
DOI = {10.3727/096504018X15336368805108}
}