@Article{096504018X15439207752093,
AUTHOR = {Xue-Yi Yang, Ye Sheng},
TITLE = {miR-101 Represses T-Cell Acute Lymphoblastic Leukemia by  Targeting CXCR7/STAT3 Axis},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {9},
PAGES = {997--1006},
URL = {http://www.techscience.com/or/v27n9/48628},
ISSN = {1555-3906},
ABSTRACT = {Although miR-101 is involved in the development and progression of T-cell acute lymphoblastic leukemia 
(T-ALL), the underlying molecular mechanisms remain unclear. In this article, we report that miR-101 expression was inversely correlated with CX chemokine receptor 7 (CXCR7) level in T-ALL. Introducing miR-101 
inhibited T-ALL cell proliferation and invasion in vitro and suppressed tumor growth and lung metastasis in 
vivo. CXCR7 was identified as a direct target of miR-101. The inhibitory effects of miR-101 were mimicked 
and counteracted by CXCR7 depletion and overexpression, respectively. Mechanistically, miR-101 targets 
CXCR7/STAT3 axis to reduce T-ALL growth and metastasis. Overall, these findings implied the potential 
application of miR-101 and CXCR7 in T-ALL treatment.},
DOI = {10.3727/096504018X15439207752093}
}