@Article{096504018X15247341491655,
AUTHOR = {Lili Zhao, Yao Zhang, Jiaoxia Liu, Wei Yin, Dan Jin, Dandan Wang, Wei Zhang},
TITLE = {miR-185 Inhibits the Proliferation and Invasion of Non-Small  Cell Lung Cancer by Targeting KLF7},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {9},
PAGES = {1015--1023},
URL = {http://www.techscience.com/or/v27n9/48630},
ISSN = {1555-3906},
ABSTRACT = {MicroRNAs (miRNAs) are short endogenous noncoding RNAs that frequently play vital roles in many cancer 
types. Herein we demonstrated that miR-185 was remarkably downregulated in NSCLC tissues compared with 
adjacent normal tissues. A lower level of miR-185 was associated with lymph node metastasis. Functional 
assays showed that upregulation of miR-185 inhibited the proliferation, colony formation, and invasion capacities of NSCLC cells in vitro. Furthermore, we found that miR-185 suppressed the epithelial–mesenchymal 
transition (EMT) process. Bioinformatics analysis and luciferase reporter gene assays revealed that Kruppellike factor 7 (KLF7) was the target of miR-185. Overexpression of miR-185 reduced the expression of KLF7 
in NSCLC cells. Upregulation of KLF7 partly neutralized the inhibitory effects of miR-185 on the proliferation 
and invasion of NSCLC. Additionally, we confirmed that miR-185 suppressed the tumor growth of NSCLC 
A549 cells in vivo. Taken together, these results demonstrate that miR-185 acts as a suppressor by targeting 
KLF7 in NSCLC.},
DOI = {10.3727/096504018X15247341491655}
}