@Article{096504019X15519249902838,
AUTHOR = {Adilijiang Maimaitiming, Ailijiang Wusiman, Abulajiang Aimudula, Xuekelaiti Kuerban, Pengcheng Su},
TITLE = {MicroRNA-152 Inhibits Cell Proliferation, Migration,  and Invasion in Breast Cancer},
JOURNAL = {Oncology Research},
VOLUME = {28},
YEAR = {2020},
NUMBER = {1},
PAGES = {13--19},
URL = {http://www.techscience.com/or/v28n1/48459},
ISSN = {1555-3906},
ABSTRACT = {The aim of the present study was to investigate the roles of microRNA-152 (miR-152) in the initiation and 
progression of breast cancer. The expression level of miR-152 was detected in human breast cancer tissue and 
a panel of human breast cancer cell lines using qRT-PCR. Results found that miR-152 expression was significantly downregulated in breast cancer tissue samples compared to adjacent noncancerous tissues as well as in 
breast cancer cell lines. Overexpression of miR-152 significantly suppressed breast cancer cell proliferation, 
migration, and invasion. Luciferase reporter assay results found that ROCK1 is a direct and functional target 
gene of miR-152 in breast cancer. In addition, downexpression of ROCK1 could inhibit breast cancer cell 
proliferation, migration, and invasion. These findings indicate that miR-152 inhibited breast cancer growth 
and metastasis through negative regulation of ROCK1 expression. These data suggest that miR-152/ROCK1 
pathway may be a useful therapeutic target for breast cancer treatment.},
DOI = {10.3727/096504019X15519249902838}
}