@Article{096504018X15213142076069,
AUTHOR = {Zhong-xin Zhou, Zu-ping Zhang, Ze-zhang Tao, Ting-zhao Tan},
TITLE = {miR-632 Promotes Laryngeal Carcinoma Cell Proliferation, Migration,  and Invasion Through Negative Regulation of GSK3b},
JOURNAL = {Oncology Research},
VOLUME = {28},
YEAR = {2020},
NUMBER = {1},
PAGES = {21--31},
URL = {http://www.techscience.com/or/v28n1/48460},
ISSN = {1555-3906},
ABSTRACT = {Laryngeal cancer, one of the most common head and neck malignancies, is an aggressive neoplasm. Increasing 
evidence has demonstrated that microRNAs (miRNAs) exert important roles in oncogenesis and progression 
of diverse types of human cancers. miR-632, a tumor-related miRNA, has been reported to be dysregulated 
and implicated in human malignancies; however, its biological role in laryngeal carcinoma remains to be elucidated. The present study aimed at exploring the role of miR-632 in laryngeal cancer and clarifying the potential 
molecular mechanisms involved. In the current study, miR-632 was found to be significantly upregulated 
both in laryngeal cancer tissues and laryngeal cancer cell lines. Functional studies demonstrated that miR-632 
accelerated cell proliferation and colony formation, facilitated cell migration and invasion, and enhanced the 
expression of cell proliferation-associated proteins, cyclin D1 and c-myc. Notably, miR-632 could directly 
bind to the 3 -untranslated region (3 -UTR) of glycogen synthase kinase 3 (GSK3 ) to suppress its expression 
in laryngeal cancer cells. Mechanical studies revealed that miR-632 promoted laryngeal cancer cell proliferation, migration, and invasion through negative modulation of GSK3 . Pearson’s correlation analysis revealed 
that miR-632 expression was inversely correlated with GSK3 mRNA expression in laryngeal cancer tissues. 
Taken together, our findings suggest that miR-632 functions as an oncogene in laryngeal cancer and may be 
used as a novel therapeutic target for laryngeal cancer.},
DOI = {10.3727/096504018X15213142076069}
}