@Article{096504019X15761480623959,
AUTHOR = {Yong Wang, Rui-Zhi Jia, Shu Diao, Jun He, Li Jia},
TITLE = {miRNA-101 Targets TGF-bR1 to Retard the Progression  of Oral Squamous Cell Carcinoma},
JOURNAL = {Oncology Research},
VOLUME = {28},
YEAR = {2020},
NUMBER = {2},
PAGES = {203--212},
URL = {http://www.techscience.com/or/v28n2/48544},
ISSN = {1555-3906},
ABSTRACT = {Despite the considerable knowledge on the involvement of microRNA-101 (miR-101) in the evolution of oral 
squamous cell carcinoma (OSCC), the underlying mechanisms remain obscure. In this study, miR-101 expression 
was markedly downregulated in the OSCC cell lines and tissues. Cell counting kit-8 (CCK-8), ethynyl deoxyuridine (EdU), and colony formation assays showed that miR-101 inhibited the proliferation of OSCC cells. Flow 
cytometry and caspase 3 activity assays indicated that miR-101 induced OSCC cell apoptosis. Transwell assays 
demonstrated that this miRNA also repressed OSCC cell migration and invasion. Moreover, tube formation 
assay showed that miR-101 abated the proangiogenesis of OSCC cells. Dual-luciferase reporter assay confirmed 
that miR-101 directly targeted transforming growth factor- receptor 1 (TGF- R1) in OSCC. Ectopic expression 
of TGF- R1 counteracted the effects of miR-101 on the OSCC cell characteristics. Thus, miR-101 significantly 
abolished the proliferation, motility, and proangiogenesis of OSCC cells and induced their apoptosis by targeting 
TGF- R1. These results imply the potential application of miR-101 in OSCC treatment.},
DOI = {10.3727/096504019X15761480623959}
}