@Article{096504020X15801233454611,
AUTHOR = {Jianing Xu, Qiyu Bo, Xiang Zhang, Dapeng Lei, Jue Wang, Xinliang Pan},
TITLE = {lncRNA HOXA11-AS Promotes Proliferation and Migration via Sponging  miR-155 in Hypopharyngeal Squamous Cell Carcinoma},
JOURNAL = {Oncology Research},
VOLUME = {28},
YEAR = {2020},
NUMBER = {3},
PAGES = {311--319},
URL = {http://www.techscience.com/or/v28n3/48534},
ISSN = {1555-3906},
ABSTRACT = {Hypopharyngeal squamous cell carcinoma (HSCC) remains one of the most lethal malignancies in the head and 
neck. Long noncoding RNA (lncRNA) HOXA11-AS is proven to function as an oncogene and a therapeutic 
target in various tumors. Our previous study and others have demonstrated that HOXA11-AS is one of the 
most upregulated lncRNAs in HSCC. However, the role of HOXA11-AS in HSCC has not yet been identified. 
The current study demonstrated that the expression of HOXA11-AS was significantly upregulated in HSCC 
tumors and was positively associated with lymph node metastasis. Moreover, functional experiments revealed 
that HOXA11-AS knockdown suppressed the proliferation and migration potential in FaDu cells. Furthermore, 
luciferase reporter gene assay combined with cellular functional experiments demonstrated that HOXA11-AS 
functioned as a molecular sponge for miR-155, and inhibition of miR-155 attenuated the suppressive effect of 
HOXA11-AS knockdown on the aggressive phenotype in HSCC. This study identifies a tumor-promoting role 
of HOXA11-AS in HSCC and suggests HOXA11-AS might be a potential diagnostic and therapeutic target 
for HSCC.},
DOI = {10.3727/096504020X15801233454611}
}