@Article{096504020X15844389264424,
AUTHOR = {Yun Qin, Yu Wang, Dongbo Liu},
TITLE = {miR-4792 Inhibits Acute Myeloid Leukemia Cell Proliferation and Invasion  and Promotes Cell Apoptosis by Targeting Kindlin-3},
JOURNAL = {Oncology Research},
VOLUME = {28},
YEAR = {2020},
NUMBER = {4},
PAGES = {357--369},
URL = {http://www.techscience.com/or/v28n4/48519},
ISSN = {1555-3906},
ABSTRACT = {It has been reported that kindlin-3 expression is closely associated with progression of many cancers and 
microRNA (miRNA) processing. However, the effects and precise mechanisms of kindlin-3 in acute myeloid 
leukemia (AML) have not been well clarified. Our study aimed to explore the interaction between kindlin-3 
and miR-4792 in AML. In our study, we found that the expression of kindlin-3 was dramatically increased in 
AML samples and cell lines, and the miR-4792 level was significantly downregulated. Interestingly, the low 
miR-4792 level was closely associated with upregulated kindlin-3 expression in AML samples. Moreover, 
introduction of miR-4792 dramatically suppressed proliferation and invasion and induced apoptosis of AML 
cells. We demonstrated that miR-4792 could directly target kindlin-3 by using both bioinformatics analysis and 
luciferase reporter assay. In addition, kindlin-3 silencing had similar effects with miR-4792 overexpression 
on AML cells. Overexpression of kindlin-3 in AML cells partially reversed the inhibitory effects of miR-4792 
mimic. miR-4792 inhibited cell proliferation and invasion and induced apoptosis of AML cells by directly 
downregulating kindlin-3 expression, and miR-4792 targeting kindlin-3 was responsible for the regulation of 
the proliferation, invasion, and apoptosis of AML cells.},
DOI = {10.3727/096504020X15844389264424}
}