@Article{096504020X15864296270581,
AUTHOR = {Donghai Zhuang, Li Liang, Hongzhan Zhang, Xianguang Feng},
TITLE = {miR-202 Suppresses Hepatocellular Carcinoma Progression via  Downregulating BCL2 Expression},
JOURNAL = {Oncology Research},
VOLUME = {28},
YEAR = {2020},
NUMBER = {4},
PAGES = {399--408},
URL = {http://www.techscience.com/or/v28n4/48522},
ISSN = {1555-3906},
ABSTRACT = {miRNAs play an important role in progression of hepatocellular carcinoma (HCC). In this work, we assessed the 
function of miR-202 in human HCC and identified BCL2 as its target. We found miR-202 expression was found significantly downregulated, while BCL2 expression was markedly upregulated in HCC tissues and cell lines (HepG2, 
Hep3B, and HCCLM3). Both miR-202 and BCL2 were closely correlated with major vascular invasion and advanced 
TNM stage as well as overall survival of HCC patients. Overexpression of miR-202 significantly inhibited cell proliferation, induced apoptosis and cell cycle arrest at the G0/G1 phase, and prevented tumor formation in a xenograft 
nude mouse model. Further, miR-202 dramatically inhibited migration, invasion, and epithelial–mesenchymal transition. miR-202 bound to the 3 -untranslated region (3 -UTR) of BCL2 mRNA and downregulated the expression 
level of BCL2 protein. Exogenous BCL2 overexpression weakened the inhibitory effects of miR-202, while inhibition of BCL2 enhanced the inhibitory effects of miR-202. In conclusion, miR-202 serves as a tumor suppressor in 
HCC progression by downregulating BCL2 expression, indicating miR-202 might be a potential target for HCC.},
DOI = {10.3727/096504020X15864296270581}
}