TY  - EJOU
AU  - Guo, Qie 
AU  - Li, Xiao 
AU  - Cui, Meng-Na 
AU  - Sun, Jia-Lin 
AU  - Ji, Hong-Yan 
AU  - Ni, Bei-Bei 
AU  - Yan, Mei-Xing 

TI  - CD13: A Key Player in Multidrug Resistance in Cancer Chemotherapy
T2  - Oncology Research

PY  - 2020
VL  - 28
IS  - 5
SN  - 1555-3906

AB  - Cancer is one of the most serious diseases that are harmful to human health. Systemic chemotherapy is an optimal therapeutic strategy for the treatment of cancer, but great difficulty has been encountered in its administration in the form of multidrug resistance (MDR). As an enzyme on the outer cell surface, CD13 is documented 
to be involved in the MDR development of tumor cells. In this review, we will focus on the role of CD13 in 
MDR generation based on the current evidence.
KW  - CD13; Multidrug resistance (MDR); Drug efflux; Chemotherapy; Reactive oxygen species;  Immune suppression

DO  - 10.3727/096504020X15919605976853