@Article{096504020X16014648664459,
AUTHOR = {Yu Sun, Wei Wang, Chenghai Zhao},
TITLE = {Frizzled Receptors in Tumors, Focusing on Signaling, Roles,  Modulation Mechanisms, and Targeted Therapies},
JOURNAL = {Oncology Research},
VOLUME = {28},
YEAR = {2020},
NUMBER = {6},
PAGES = {661--674},
URL = {http://www.techscience.com/or/v28n6/48502},
ISSN = {1555-3906},
ABSTRACT = {Wnt molecules play crucial roles in development and adult homeostasis through their receptors Frizzled proteins 
(Fzds). Fzds mediate canonical b-catenin pathway and various noncanonical b-catenin-independent pathways. 
Aberrant Fzd signaling is involved in many diseases including cancer. Wnt/b-catenin is a well-established oncogenic pathway involved in almost every aspect of tumor development. However, Fzd-mediated noncanonical Wnt 
pathways function as both tumor promoters and tumor suppressors depending on cellular context. Fzd-targeted 
therapies have proven to be effective on cultured tumor cells, tumor cell xenografts, mouse tumor models, and 
patient-derived xenografts (PDX). Moreover, Fzd-targeted therapies synergize with chemotherapy in preclinical 
models. However, the occurrence of fragility fractures in patients treated with Fzd-targeted agents such as OMP-
54F28 and OMP-18R5 limits the development of this combination. Along with new insights on signaling, roles, 
and modulation mechanisms of Fzds in human tumors, more Fzd-related therapeutic targets will be developed.},
DOI = {10.3727/096504020X16014648664459}
}