@Article{096504020X15986099915822,
AUTHOR = {Ching-Wen Huang, Cheng-Jen Ma, Wei-Chih Su, Yi-Ting Chen, Hsiang-Lin Tsai, Yung-Sung Yeh, 
Tsung-Kun Chang, Wen-Hung Hsu, Fang-Jung Yu, Jaw-Yuan Wang},
TITLE = {Prognostic Value of EGFR Expression for Patients With Stage III Colorectal  Cancer Receiving Fluoropyrimidine Metronomic Maintenance Therapy After  Radical Resection and Adjuvant Oxaliplatin-Based Chemotherapy},
JOURNAL = {Oncology Research},
VOLUME = {28},
YEAR = {2020},
NUMBER = {7-8},
PAGES = {701--714},
URL = {http://www.techscience.com/or/v28n7-8/48462},
ISSN = {1555-3906},
ABSTRACT = {This study evaluated the survival effects of metronomic maintenance therapy with oral fluoropyrimidine in 
patients with stage III colorectal cancer (CRC) according to epidermal growth factor receptor (EGFR) expression. 
We enrolled 197 patients with stage III CRC who had undergone radical resection and FOLFOX regimen adjuvant 
chemotherapy. The clinicopathological features and effects of metronomic maintenance therapy with oral capecitabine (daily dose of 850 mg/m2
, twice daily, on days 1–14 every 3 weeks for 6 months) on survival according to 
treatment group and EGFR expression were analyzed. By conducting an in vitro cell line study and in vivo study 
through knockout of the EGFR gene, we analyzed the capacities of cell proliferation and migration. Relapse and 
survival were significantly more common in the FOLFOX group. Metronomic maintenance therapy was a significantly independent associated factor of relapse and survival as well as a prognostic factor of disease-free survival 
and overall survival. Significant intergroup differences in survival were only observed in patients with positive 
EGFR expression. Thus, our findings suggest EGFR expression is a prognostic factor in patients with stage III 
CRC receiving metronomic maintenance therapy. Analysis of EGFR expression in these patients helps identify 
potential candidates who may receive the optimal survival benefit from metronomic maintenance therapy.},
DOI = {10.3727/096504020X15986099915822}
}