@Article{096504020X16100888208039,
AUTHOR = {Huiling Wang, Xin Hu, Feng Yang, Hui Xiao},
TITLE = {miR-325-3p Promotes the Proliferation, Invasion, and EMT of  Breast Cancer Cells by Directly Targeting S100A2},
JOURNAL = {Oncology Research},
VOLUME = {28},
YEAR = {2020},
NUMBER = {7-8},
PAGES = {731--744},
URL = {http://www.techscience.com/or/v28n7-8/48464},
ISSN = {1555-3906},
ABSTRACT = {This study was designed to investigate the precise mechanisms of miR-325-3p/S100A2 axis in breast cancer 
(BC). In this study, we found that the level of miR-325-3p was dramatically increased in BC tissues and cell 
lines, and the expression of S100A2 was significantly decreased. Also, the high level of miR-325-3p was 
closely associated with low expression of S100A2 in BC tissues. Moreover, introduction of miR-325-3p significantly promoted proliferation, invasion, and EMT of BC cells. Bioinformatics analysis predicted that the 
S100A2 was a potential target gene of miR-325-3p. Luciferase reporter assay demonstrated that miR-325-3p 
could directly target S100A2. In addition, miR-325-3p overexpression had similar effects with knockdown of 
S100A2 on BC cells. Overexpression of S100A2 in BC cells partially reversed the promoted effects of miR-
325-3p mimic. Overexpression of miR-325-3p promoted cell proliferation, invasion, and EMT of BC cells by 
directly downregulating S100A2 expression.},
DOI = {10.3727/096504020X16100888208039}
}