TY  - EJOU
AU  - Wang, Huiling 
AU  - Hu, Xin 
AU  - Yang, Feng 
AU  - Xiao, Hui 

TI  - miR-325-3p Promotes the Proliferation, Invasion, and EMT of  Breast Cancer Cells by Directly Targeting S100A2
T2  - Oncology Research

PY  - 2020
VL  - 28
IS  - 7-8
SN  - 1555-3906

AB  - This study was designed to investigate the precise mechanisms of miR-325-3p/S100A2 axis in breast cancer 
(BC). In this study, we found that the level of miR-325-3p was dramatically increased in BC tissues and cell 
lines, and the expression of S100A2 was significantly decreased. Also, the high level of miR-325-3p was 
closely associated with low expression of S100A2 in BC tissues. Moreover, introduction of miR-325-3p significantly promoted proliferation, invasion, and EMT of BC cells. Bioinformatics analysis predicted that the 
S100A2 was a potential target gene of miR-325-3p. Luciferase reporter assay demonstrated that miR-325-3p 
could directly target S100A2. In addition, miR-325-3p overexpression had similar effects with knockdown of 
S100A2 on BC cells. Overexpression of S100A2 in BC cells partially reversed the promoted effects of miR-
325-3p mimic. Overexpression of miR-325-3p promoted cell proliferation, invasion, and EMT of BC cells by 
directly downregulating S100A2 expression.
KW  - Breast cancer (BC); MicroRNA-325-3p; S100A2; Proliferation;  Epithelial–mesenchymal transition (EMT)

DO  - 10.3727/096504020X16100888208039