@Article{096504021X16274672547967,
AUTHOR = {Hui Li, Han-Han Li, Qian Chen, Yu-Yang Wang, Chang-Chang Fan, Yuan-Yuan Duan, 
You Huang, Hui-Min Zhang, Jia-Peng Li, Xiao-Yu Zhang, Yuan Xiang, Chao-Jiang Gu, Li Wang, Xing-Hua Liao, Tong-Cun Zhang},
TITLE = {miR-142-5p Inhibits Cell Invasion and Migration by Targeting  DNMT1 in Breast Cancer},
JOURNAL = {Oncology Research},
VOLUME = {28},
YEAR = {2020},
NUMBER = {9},
PAGES = {885--897},
URL = {http://www.techscience.com/or/v28n9/48483},
ISSN = {1555-3906},
ABSTRACT = {Abnormal cell proliferation caused by abnormal transcription regulation mechanism seems to be one of the 
reasons for the progression of breast cancer and also the pathological basis. MicroRNA-142-5p (miR-142-5p) 
is a low-expressed miRNA in breast cancer. The role of MKL-1’s regulation of DNMT1 in breast cancer cell 
proliferation and migration is still unclear. MKL-1 (myocardin related transcription factor A) can bind to the 
conserved cis-regulatory element CC (A/T) 6GG (called CarG box) in the promoter to regulate the transcription 
of miR-142-5p. The expressions of miR-142-5p and MKL-1 are positively correlated. In addition, it has been 
proved that DNMT1 is the target of miR-142-5p, which inhibits the expression of DNMT1 by targeting the 
3¢-UTR of DNMT1, thereby forming a feedback loop and inhibiting the migration and proliferation of breast 
cancer. Our data provide important and novel insights into the MKL-1/miR-142-5p/DNMT1/maspin signaling 
pathway and may become a new idea for breast cancer diagnosis, treatment, and prognosis.},
DOI = {10.3727/096504021X16274672547967}
}