@Article{096504022X16414984936773,
AUTHOR = {Tao Wang, Fan Shi, JiQuan Wang, Zi Liu, Jin Su},
TITLE = {Kallistatin Suppresses Cell Proliferation and Invasion and Promotes  Apoptosis in Cervical Cancer Through Blocking NF-κB Signaling},
JOURNAL = {Oncology Research},
VOLUME = {28},
YEAR = {2020},
NUMBER = {9},
PAGES = {969--970},
URL = {http://www.techscience.com/or/v28n9/48490},
ISSN = {1555-3906},
ABSTRACT = {Kallistatin has been recognized as an endogenous angiogenesis inhibitor and exerts pleiotropic effects in inhibiting tumor growth, migration, apoptosis, and inflammation. The purpose of the present study was to investigate the potential role and mechanisms of kallistatin in cervical cancer. We demonstrated that kallistatin 
effectively inhibited cell proliferation and enhanced apoptosis in a dose-dependent manner. Additionally, kallistatin suppressed migration and invasion activities and markedly reduced the expression of matrix-degrading 
metalloproteinases, progelatinase (MMP-2), MMP-9, and urokinase-type PA (uPA). Kallistatin reversed the 
epithelial–mesenchymal transition (EMT) and caused the upregulation of epithelial markers such as E-cadherin 
and inhibited mesenchymal markers such as N-cadherin and vimentin. Moreover, kallistatin led to a marked 
decrease in the expression of vascular endothelial growth factor (VEGF) and HIF-1a. In a xenograft mouse 
model, kallistatin treatment reduced tumor growth. Importantly, kallistatin strikingly impeded NF-kB activation by suppressing IkBk degradation and the level of phosphorylation of p65. Interestingly, similar to kallistatin, treatment with PDTC (an inhibitor of NF-kB) also attenuated cell invasion and migration. Taken together, 
these findings suggest that kallistatin suppresses cervical cancer cell proliferation, migration, and EMT and 
promotes cell apoptosis by blocking the NF-kB signaling pathway, suggesting that kallistatin may be a novel 
therapeutic target for cervical cancer treatment.},
DOI = {10.3727/096504022X16414984936773}
}