@Article{096504022X16414984936791,
AUTHOR = {Wei Song, Jia-Zhuan Mei, Mingzhi Zhang},
TITLE = {Long Noncoding RNA PlncRNA-1 Promotes Colorectal Cancer Cell  Progression by Regulating the PI3K/Akt Signaling Pathway},
JOURNAL = {Oncology Research},
VOLUME = {28},
YEAR = {2020},
NUMBER = {9},
PAGES = {971--972},
URL = {http://www.techscience.com/or/v28n9/48491},
ISSN = {1555-3906},
ABSTRACT = {Accumulating evidence has indicated that long noncoding RNA (lncRNA) PlncRNA-1 plays an important 
regulatory role in cancers. However, the expression and biological functions of PlncRNA-1 in colorectal cancer 
(CRC) are still unclear. In the present study, we determined the expression of PlncRNA-1 in CRC and explored 
the function of PlncRNA-1 on CRC cell progression. The results showed that PlncRNA-1 was significantly 
increased in CRC tissues and cell lines; high PlncRNA-1 expression was associated with depth of invasion, 
lymph node metastasis, and TNM stage of CRC patients. Kaplan–Meier curve analysis showed that patients 
with high PlncRNA-1 expression had a poor overall survival. PlncRNA-1 knockdown remarkably reduced 
cell proliferation, migration, and invasion and promoted cell apoptosis in vitro. In vivo xenograft experiments 
showed that PlncRNA-1 inhibition significantly suppressed tumor growth. Finally, we used an agonist (740Y-P) 
of the PI3K/Akt signaling pathway; function assays showed that PlncRNA-1 exerted its effects by targeting the 
PI3K/Akt signaling pathway in CRC. Taken together, our data suggested that PlncRNA-1 might act as an oncogene in CRC progression and serve as a potential biomarker and therapeutic target for the treatment of CRC.},
DOI = {10.3727/096504022X16414984936791}
}