@Article{or.2022.03563,
AUTHOR = {YANG ZHANG, LIXIA MA, TINGTING ZHANG, PEIDONG LI, JIABIN XU, ZHUO WANG},
TITLE = {Long noncoding RNA TFAP2A-AS1 exerts promotive effects in non-small cell lung cancer progression via controlling the microRNA-548a-3p/CDK4 axis as a competitive endogenous RNA},
JOURNAL = {Oncology Research},
VOLUME = {29},
YEAR = {2021},
NUMBER = {2},
PAGES = {129--139},
URL = {http://www.techscience.com/or/v29n2/48802},
ISSN = {1555-3906},
ABSTRACT = {In this study, we mainly focus on probing expression profile and detailed functions of long non-coding RNA
TFAP2A antisense RNA 1 (TFAP2A-AS1) in non-small cell lung cancer (NSCLC). Moreover, the mechanisms played by
TFAP2A-AS1 were unraveled comprehensively. Herein, a notable overexpressed TFAP2A-AS1 in NSCLC was observed
by TCGA and our own cohort. An increased TFAP2A-AS1 level displayed a negative correlation with the overall survival
of patients with NSCLC. Loss-of-function approaches illustrated that the absence of TFAP2A-AS1 weakened NSCLC cell
proliferation, colony formation, migration and invasion in vitro. Also, interference of TFAP2A-AS1 caused in vivo tumor
growth suppression. Mechanistically, TFAP2A-AS1 could negative regulate microRNA-584-3p (miR-584-3p) as a
competitive endogenous RNA. Furthermore, cyclin-dependent kinase 4 (CDK4), a direct target of miR-584-3p, was
positively controlled by TFAP2A-AS1 in a miR-5184-3p-dependent manner. Rescue function experiments
corroborated that the anticancer activities of TFAP2A-AS1 deficient on the oncogenicity of NSCLC cells were
reversed by downregulating miR-584-3p or overexpressing CDK4. To sum up, TFAP2A-AS1 exhibits cancerpromoting roles in NSCLC through the adjustment of miR-584-3p/CDK4 axis.},
DOI = {10.32604/or.2022.03563}
}