TY - EJOU AU - HEMMAT, NIMA AU - DOUSTVANDI, MOHAMMAD AMIN AU - ASADZADEH, ZAHRA AU - MOKHTARZADEH, AHAD AU - BARADARAN, BEHZAD AU - BAGHI, HOSSEIN BANNAZADEH TI - Suppression of human papillomavirus type 16 E5 oncoprotein: A promising step in fostering the treatment of cervical cancer T2 - Oncology Research PY - 2021 VL - 29 IS - 2 SN - 1555-3906 AB - Cervical cancer is a growing global disease in developing countries. Persistent infection with human papillomaviruses (HPV) is an essential causative agent in this type of cancer. Several studies demonstrate HPV E5 oncoprotein can impress the normal life cycle of HPV-infected cells by targeting some pivotal cellular signaling pathways, such as the epidermal growth factor receptor (EGFR) signaling pathway. In this study, we used E5-siRNA to knockdown that essential oncogene and considered the effect of E5 silencing on proliferation, apoptosis, cell cycle, apoptosis-related gene expression, and the initiator of the EGFR signaling pathway in cervical cancer cells. The results demonstrate that E5 plays an essential role in the proliferation and inhibited apoptosis in cervical cancer. Furthermore, silencing E5 reduces proliferation, increases apoptosis, and elevates related-genes expression of these malignant cells. Overall, E5 suppression may be appropriate for ameliorating cervical cancer progression. KW - Human papillomavirus KW - e5 transforming protein KW - epidermal growth factor receptor KW - cervical cancer KW - CaSki DO - 10.32604/or.2022.023346