@Article{or.2022.026141,
AUTHOR = {SHOUKAI YU, LINGMEI QIAN, JUN MA},
TITLE = {Comprehensive analysis of the expression and prognosis for APOE in malignancies: A pan-cancer analysis},
JOURNAL = {Oncology Research},
VOLUME = {30},
YEAR = {2022},
NUMBER = {1},
PAGES = {13--22},
URL = {http://www.techscience.com/or/v30n1/50705},
ISSN = {1555-3906},
ABSTRACT = {Apolipoprotein E (<i>APOE</i>), a gene identified as one of the strongest genetic factors contributing to the risk determinant of developing late-onset Alzheimer’s disease (AD), may also contribute to the risk of cancer. However, no pan-cancer analysis has been conducted specifically for the <i>APOE</i> gene. In this study, we investigated the oncogenic role of the <i>APOE</i> gene across cancers by GEO (Gene Expression Omnibus) and TCGA (The Cancer Genome Atlas). Based on the available data, we found that most cancer types overexpress <i>APOE</i>, and clear associations exist between the expression level of <i>APOE</i> and prognosis in tumor patients. The expression of <i>APOE</i> also correlates with certain gender-associated tumors including, ovarian cancer, uterine carcinosarcoma, and breast cancer. However, there is a significant negative association between cancer-associated fibroblast infiltration levels and the expression level of <i>APOE</i> in testicular germ cell tumors. Moreover, acute inflammatory response and protein-activation cascade-associated functions play an important role in the functional mechanisms of APOE. The present pan-cancer analysis of APOE shows that the protein phosphorylation, DNA methylation, and genetic alterations of APOE have a significant clinical relevance for survival prognosis and immune cell infiltration. This novel pan-cancer study outlines the current understanding of APOE oncogenic roles across thirty-three cancers and highlights the complex association between AD and cancers.},
DOI = {10.32604/or.2022.026141}
}