@Article{or.2022.027900,
AUTHOR = {JIATENG ZHONG, JINGYU GUO, XINYU ZHANG, SHUANG FENG, WENYU DI, YANLING WANG, HUIFANG ZHU},
TITLE = {The remodeling roles of lipid metabolism in colorectal cancer cells and immune microenvironment},
JOURNAL = {Oncology Research},
VOLUME = {30},
YEAR = {2022},
NUMBER = {5},
PAGES = {231--242},
URL = {http://www.techscience.com/or/v30n5/51415},
ISSN = {1555-3906},
ABSTRACT = {Lipid is a key component of plasma membrane, which plays an important role in the regulation of various cell
biological behaviors, including cell proliferation, growth, differentiation and intracellular signal transduction. Studies
have shown that abnormal lipid metabolism is involved in many malignant processes, including colorectal cancer
(CRC). Lipid metabolism in CRC cells can be regulated not only by intracellular signals, but also by various
components in the tumor microenvironment, including various cells, cytokines, DNA, RNA, and nutrients including
lipids. In contrast, abnormal lipid metabolism provides energy and nutrition support for abnormal malignant growth
and distal metastasis of CRC cells. In this review, we highlight the remodeling roles of lipid metabolism crosstalk
between the CRC cells and the components of tumor microenvironment.},
DOI = {10.32604/or.2022.027900}
}