TY  - EJOU
AU  - SHAABAN, NADIA Z. 
AU  - IBRAHIM, NASHWA K. 
AU  - SAADA, HELEN N. 
AU  - EL-RASHIDY, FATMA H. 
AU  - SHAABAN, HEBATALLAH M. 
AU  - ELBAKARY, NERMEEN M. 
AU  - KODOUS, AHMAD S. 

TI  - The Implication of microRNAs as non-invasive biomarkers in 179 Egyptian breast cancer female patients
T2  - Oncology Research

PY  - 2022
VL  - 30
IS  - 6
SN  - 1555-3906

AB  - <b>Background:</b> MicroRNAs (miRs) are small (19–25 nucleotides), non-protein coding RNAs that regulate gene
expression, and thus play essential roles in cell cycle progression. The evidence has demonstrated that the expression of
several miRs is dysregulated in human cancer.<b> Methods: </b>The study includes 179 female patients and 58 healthy women
Patients were identified as luminal A, B, Her-2/neu, and basal-like, as well as classified into I, II, and III stages. Analysis of
the expression fold change of miR-21 and miR-34a with molecular markers, including the oncogene Bcl-2 (B-cell
lymphoma 2) and the tumor suppressor genes BRCA1 (breast cancer susceptibility gene 1), BRCA2 (breast cancer
susceptibility gene 2), and the tumor suppressor protein p53, was carried out for all patients, pre- and postchemotherapy, and for all healthy women. <b>Results:</b> At diagnosis (pre-chemotherapy), miR-21 was up-regulated (<i>p</i> <
0.001), while miR-34a was down-regulated (<i>p</i> < 0.001). Post-chemotherapy, the expression of miR-21 decreased
significantly (<i>p</i> < 0.001), while the expression of miR-34a increased significantly (<i>p</i> < 0.001). <b>Conclusion: </b>miR-21 and
miR-34a may be helpful to non-invasive biomarkers to evaluate the response of breast cancer to chemotherapy.
KW  - miR-21 and miR-34a
KW  -  Breast-cancer
KW  -  BRCA1 and BRCA2
KW  -  Bcl-2
KW  -  p53

DO  - 10.32604/or.2022.027277