@Article{or.2022.027359,
AUTHOR = {YUNAN MAO, JINZE SHEN, LI FANG, FENG ZHU, SHIWEI DUAN},
TITLE = {The tumor suppressor role and ceRNA network of miR-1294 in cancer},
JOURNAL = {Oncology Research},
VOLUME = {31},
YEAR = {2023},
NUMBER = {1},
PAGES = {1--12},
URL = {http://www.techscience.com/or/v31n1/51750},
ISSN = {1555-3906},
ABSTRACT = {miRNAs are endogenous small RNAs that are important regulators of gene expression. miR-1294 was found to
be significantly down-regulated in 15 cancers and regulated by 21 upstream regulators. miR-1294 affects the proliferation,
migration, invasion, and apoptosis of cancer cells. The target genes of miR-1294 are involved in the PI3K/AKT/mTOR,
RAS, and JAK/STAT signaling pathways. Six target genes of miR-1294 are the targets of a variety of drugs. Low expression
of miR-1294 is associated with resistance to cisplatin and TMZ and a poorer prognosis in patients with ESCC, GC, EOC,
PDAC, or NSCLC. Therefore, this work outlines the molecular mechanisms and provides a basis for the clinical
significance of the tumor suppressor miR-1294 in cancer.},
DOI = {10.32604/or.2022.027359}
}